Lung Program
We are extending the telomeres of lung stem cells to enable them to regenerate the lung.
Rejuvenation
Technology
Rejuvenation technology refers to a broad category of scientific and medical advancements aimed at restoring, revitalizing, or enhancing the health, appearance, or functionality of various biological systems.
Nanoparticles deliver mRNA to the lung stem cells, extending their telomeres in hours sufficiently to reverse years of telomere shortening.
The stem cells are able to divide a few more times to continue to repair and regenerate the lung.
Daughter cells of the stem cell differentiate into AT1 cells that build and repair the walls of lung alveoli.
This technology can target aging-related degeneration, tissue damage, or other health-related issues. Here are some key aspects:
- Anti-Aging
- Stem Cell Therapy
- Regenerative Medicine
- Genetic Engineering
- Senescence Reversal
- Nanotechnology
- Advanced Therapies
- Cosmetic and Aesthetic Rejuvenation
*Note: As with any medical or scientific advancement, it should be used in a responsible and regulated manner to ensure safety and efficacy.
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Understanding chronic lung damage
Chronic lung damage is a critical health concern that affects millions of individuals worldwide. Throughout life, our lungs are exposed to a multitude of chronic insults, which can lead to long-term health issues. It’s essential to understand the causes, consequences, and prevention of chronic lung damage. In this section, we’ll delve into the various factors that contribute to this condition and how you can safeguard your lung health.
Here’s a breakdown of the key aspects of understanding chronic lung damage:
Causes
Symptoms
Interstitial Lung Disease (ILD)
Bronchiectasis
Diagnosis
Treatment
The lung stem cells need to divide to repair the damage
In the human body, the regenerative capacity of lung tissue is more limited compared to some other tissues like the skin or the liver. While there are ongoing studies on lung stem cells and their potential role in regeneration, the regenerative ability of lung tissue is not as robust.
In the context of lung damage and repair, the primary mechanism for healing typically involves the activation and proliferation of existing lung cells rather than the division of specialized lung stem cells.
When cells divide their telomeres shorten
Stem cells play a crucial role in tissue repair and regeneration by dividing to produce new cells that can replace damaged or lost cells. When tissues in the body are damaged due to injury, disease, or normal wear and tear, the body’s natural response is to initiate a repair process. Stem cells are often involved in this process, depending on the type of tissue and its regenerative capacity.
Injury or Damage
Activation of Stem Cells
Cell Division
Differentiation
Tissue Regeneration
Vision: Screen, Treat, Prevent Interstitial Lung Disease
At-risk patient comes for check-up
High Risk for ILD
Telomerase therapy
Disease is prevented
1M Patients/year
When telomeres become too short the stem cells can no longer divide to regenerate the lung
Telomeres are protective caps on the ends of chromosomes, and they play a crucial role in the replication and division of cells, including stem cells. When telomeres become too short, it can lead to a limitation in the ability of cells, including stem cells, to divide and regenerate tissues.
Here’s how it works in the context of stem cells and lung regeneration:
Telomere Shortening
Cell Division and Telomeres
Stem Cells and Regeneration
Effect on Lung Regeneration
Fibroblasts fill the resulting void with fibrosis
Fibrosis is a common outcome of chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) and can also occur as a result of chronic exposure to lung irritants, like cigarette smoke. Excessive fibrosis in the lungs can lead to reduced lung capacity and impaired respiratory function. Treatments for fibrosis often focus on managing the underlying condition, reducing inflammation, and in some cases, attempting to slow or reverse the fibrotic process.
Injury or Damage
Activation of Stem Cells
Cell Division
Differentiation
Tissue Regeneration
IPF patients have very short telomeres
Certain IPF (Idiopathic Pulmonary Fibrosis) patients have been found to exhibit a distinct characteristic: significantly shorter telomeres. Telomeres are protective caps at the ends of chromosomes that naturally shorten over time. In some cases, abnormally short telomeres have been associated with IPF. Learn more about the link between telomeres and IPF, and how it impacts treatment and care for patients. Understanding these factors is a crucial step towards advancing the management of this complex lung condition.
Telomere length predicts survival of IPF patients
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In the mouse model of pulmonary fibrosis telomere extension using telomerase mRNA almost entirely preserves healthy lung tissue, reduces fibrosis, and increases survival
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Telomerase mRNA extends lung stem cell telomeres so they can divide to regenerate the lung
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